Sentence examples for be based on toxicity from inspiring English sources

Other results suggest that B6.SOD1 motor neurons that innervate fast type motor units are more susceptible to degeneration in SOD1G93A mice, an effect that could be based on toxicity of fast type muscle fibers [6], [10], [21].

Because toxicogenomics data will be most valuable for predictive toxicology and elucidating toxicologically relevant MOAs for additional chemicals, a future database should be based on toxicity testing and monitoring protocols commonly used for regulatory purposes (e.g., global pesticide registrations), as well as chemicals with well-known MOAs such as 17β-estradiol and dioxin.

The level, which is based on toxicity studies in rabbits, will allow regulators to better assess levels of glyphosate in food and other sources, the agency says.

If such an effect is based on toxicity mediated by fast-type muscle fibers, then the overall successful innervation of B6.SOD1 transplanted muscle by wild-type motoneurons could be based on a failure of fast-type muscle fibers to regenerate in the transplanted muscles.

Dose finding was based on toxicity probability intervals [ 14].

Early stopping rules were based on toxicity grade and serious AEs.

The highest concentrations tested were either 250 or 150 μg/L and were based on toxicity data in fish.

Dose reductions for both UFT® and oxaliplatin were based on toxicity from the previous cycle and graded according to NCI-CTC 2 classification.

According to the U.S. EPA, "the RPF method uses empirically derived scaling factors that are based on toxicity studies of the effect and exposure conditions of interest in the assessment," whereas the TEF is based on "extensive mechanistic information that shows all the toxic effects of concern share a common mode of action" (U.S. EPA 2000).

During the study, the dose modification criteria were predefined and were based on toxicities.

Dose-limiting toxicity was based on toxicities during the first cycle of CYT997 and was defined as grade 4 neutropenia lasting ⩾5 days, associated with fever (⩾38.5°C) or requiring antibiotics; grade 4 thrombocytopenia (grade 3 if bleeding); or drug-related non-haematological toxicity ⩾grade 3 (excluding nausea, vomiting and diarrhoea, unless receiving optimal supportive care).