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Computer prediction of peptide epitopes can be based on known motifs for peptide sequences that bind to a certain MHC molecule, on algorithms using experimental data as a training set, or on structure-based approaches.
Since no controlled clinical trials exist to identify an optimal antibiotic regimen, decisions must be based on known in vitro sensitivities together with anecdotal clinical evidence.
The interviews show that the exercises need to be structured and that efforts should mainly be based on known routines, that is, applying the repetitive knowledge that every profession exercises regularly.
The selection of bioassays to be used as well as the specific details of experimental design can be based on known mechanisms of action of the parent compounds.
The plant is assumed to be the Nth plant, meaning that it is considered to be based on known technology at the time of construction (N could be 3-6 depending on the size and complexity of the demonstration plant).
Calculation of the patients' absolute risk of cardiovascular events in 10 years, which is a proxy measure of actual health gain, will be based on known and available determinants: diabetes, age, sex, smoking, blood cholesterol level and systolic blood pressure.
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It is drama, but everything is based on known facts.
In short, right action is based on known goods and bads, not a set that contains unknown goods and bads.
Wherever possible, these functions were based on known (evidence-based) regional or national impact models.
This can be realized in many different ways, and one of them is a triangulation method that is based on known reference object positions.
One project was based on known technology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com