46 Secondly, patients with the most severe renal dysfunction (estimate glomerular filtration rate <30 mL/min/1.73 m) were not included in randomized trials of novel anticoagulants, so these agents should be avoided in such patients.
These limitations could be avoided with a randomized study design, but this was impractical in our ICUs.
In theory, selection bias can only be avoided by conducting a randomized controlled trial.
In theory, of course, selection bias can only be avoided by conducting a randomized controlled trial.
However, it has been previously reported in the Cochrane reviews that the use of mesh for posterior vaginal wall prolapse should be avoided [ 5]; thus, a randomized controlled clinical trial is needed to confirm the advantage of our PTVM surgery.
Packet looping, which is inherent in a randomized routing protocol, can be avoided by recording a packet's traversed path in it incrementally so that a forwarding filtering can be implemented.
First, the study was not a randomized controlled trial and thus selection and unobserved confounding biases could not be avoided.
Hence, the highly controlled conditions of a randomized, double blind study were avoided.
An open randomized trial showed beneficial effects of ACE inhibitors ± thiazide in hypertensive people, i.e. BMD loss was avoided and metabolic profile was improved.
It would appear that, in the absence of prospective, randomized trial data, liberal fluid therapy is best avoided in the context of severe malaria.
