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It is not clear in this model how the enhancers would be available to activate H19 expression.
The up regulation of DIO3 in adipose tissue of juvenile LL chickens (1 11 wk) suggests that less T3 would be available to activate THRSPA transcription, which was observed in the LL.
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Although we noted no changes in the levels of beclin-1 in this study, reduced levels of Bcl-2 and Bcl-xL indicate more beclin-1 is available to activate the enzyme Vps34 and to induce the formation of autophagosomes.
A point to consider when using inducible systems is that a wide variety of options are available to activate them.
Gi/o coupled GPCRs on the other hand generate Gβγ without degrading PIP2 so both necessary ligands are available to activate GIRK.
Initiation of SICs within 1 min suggests at least in the context of RVD measurements that sufficient glutamate is available to activate NMDARs before VRAC ever have a chance to open.
As a working hypothesis, it appears that Swi6 is available to activate DNA damage response genes such as Rfx1, ensuring they are present at crucial times in the cell cycle.
In this scenario, in the absence of one or more qrr genes, increased levels of this putative transcription factor(s) would be available to bind and activate the expression of the remaining qrr promoters.
It is thought that the proposed benefit ban would be available to all EU states, and be activated when migration levels were deemed high enough to put public services or welfare systems under severe strain.
If the G6PD-regulated PPP is activated, more NADPH will be available to reduce ROS and protect cells from DNA damage.
The size of the depolarizing sag is an index of the degree of activation of Ih, a decreased size implying that fewer HCN channels are available to be activated by the hyperpolarizing step because more were already active at the holding potential.
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CEO of Professional Science Editing for Scientists @ prosciediting.com