If the compound was available in complex form, only one of the largest fragments was retained.
The human SPR crystal structure is available in complex with NADP+ in a hexameric assembly (unpublished data, PDB: 1Z6Z).
The crystal structures of both the historic 1918 NA as well as the avian flu NA are available in complex with currently used drugs.
Another challenge is that, even when good initial estimates of parameters values are available, in complex models the verification for identifiability problems (e.g., nonsignificant parameters or parameters correlation derived from experimental design) is a conceptual and numerical arduous task.
However, the interpretation of the mass spectra (i.e. the confirmation of molecular weight) can be difficult when only traces of a gas are available in complex gas mixtures, such as air.
It is also unclear how much office space will be available in the new complex for nonprofit groups to rent.
When combined with genetics, the MCCP approach also allows one to study and even identify protein complexes in their 'native environment' by analyzing the entire mitotic chromosome fraction without requiring that protein complexes be available in soluble form.
Adequate step-down facilities, such as dialysis and respiratory support, should be available in order to accept patients with complex needs and would enable earlier and safer discharge from intensive care.
While not contained in the Prp24-U6 sthecture, the distal 3′-end of U6 snRNA is available in that complex for binding the LSm proteins, consistent with the observation of a stable Prp24-LSm-U6 snRNA complex in yeast (Vidal et al., 1999).
(A small number of rental CCRCs have no entrance fee, and all services are pay-as-you-go. Plus, while nursing and assisted living beds are available in the complex, you're not guaranteed one).
