The lung injury could be attributed to acute left ventricular failure and increased pulmonary vascular permeability secondary to the release of inflammatory mediators.
Importantly, this finding could not be attributed to an elevated ventricular rate as both groups of animals underwent AV node ablation and the ventricles were paced at 100 bpm in both the AF and control groups.
The improvement in global haemodynamics by inhaled iloprost can also, at least partly, be attributed to the phenomenon of ventricular interdependence.
They also chose among the following therapeutic options, according to the therapeutic algorithm used in our ICU: volume expansion in the case of hypovolemia, vasopressors when there was right ventricular failure or when the acute circulatory failure could neither be attributed to hypovolemia nor to left ventricular dysfunction, and/or inotropes in the case of left ventricular failure.
A higher cardiac output after weaning from cardiopulmonary bypass was observed in the lidocaine group; this may be attributed to the lower incidence of reperfusion ventricular fibrillation and consequently the lower need for defibrillation by electric countershocks.
In our opinion the decrease in left ventricular end diastolic diameter (LVEDD) and improvement in left ventricular function can be attributed to the unloading of the left ventricle.
For the cases presented herein, the postoperative changes in ventricular volume can be attributed to the adjustments of the tissue to the reduced intraventricular pressure condition.
The lack of significance between advanced PD and controls, when assessed using ventricular fluids collected at autopsy, could be attributed to a number of factors, including cohort size, antibodies used, or use of autopsy ventricular fluid, which has a different protein composition from lumbar CSF [ 31].
Exposure to 100 μM BPA resulted in complete AV block and QRS interval widening, which is consistent with slowed ventricular conduction that may be attributed to reduced gap junction conductance (Gillum et al. 2009), reduced sodium channel activity, and activations that originate outside the specialized conduction system.
