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In this study, we examined whether differences in TLR4 expression levels may result from TLR4 promoter sequence variation and if diversity of innate immune responses could be attributed to variant TLR4 expression.
To consider the possibility that high dN/ dS ratios might be attributed to variant calling on paralogous gene copies, we examined observed heterozygosity (HO) in high- dN/ dS genes versus all other genes.
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The variability in levels of serum MBL in lupus patients could be attributed to variants in the MBL 2 gene [ 31, 32].
Rare monogenic diseases cannot be attributed to variants that are common, though such variants may contribute to the risk of common complex diseases, or act as modifiers of rare disease.
The majority of AMD genetic risk is attributed to variants of several components of the complement cascade; of which CFH, CFB, CFI, C2, and C3 are differentially expressed in the wound response model.
As neither facial variant was more likely to occur in either rough or gentle play, such exact matching cannot be attributed to particular variants only occurring in particular contexts.
A previous claim that haplotype-dependent mRNA levels cannot be attributed to intragenic variants and must therefore reflect the VNTR variability (Marchand and Polychronakos 2007; Pugliese et al. 1997; Vafiadis et al. 1997) is convincingly refuted by this and many previous studies (Furger et al. 2002; Kwek et al. 2002; Lu and Cullen 2003) (and references therein).
Common diseases may be attributed to combinations of variant alleles, but there are few model systems where the interactions among such variants can be studied in controlled genetic crosses.
More than 60% of the myopathy cases could be attributed to the mutated variant [ 8].
These findings imply that more than 60% of these statin-induced myopathy cases could be attributed to the C variant.
This accounts for the decrease in positivity for ZnT8A with duration of disease and earlier age at diagnosis in the statistical association tests, such that all positive associations obtained can be attributed to the genetic variant tested.> -wrap-foot> numberer of samples A subset of 1,307 cases with ZnT8A measurements had previously been tested for GADA and IA-2A [ 14, 21].
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