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Next, we evaluated whether WFA-induced apoptosis could be attributed to tumor cell loss of adhesion and detachment from the culture plate, resulting in anoikis.
These differences could possibly be attributed to tumor type specific divergences in signaling cascades, or in mechanisms of acquired cisplatin resistance.
It may also be attributed to tumor heterogeneity in which some tumor cells may continue to express functional hERα while other cells may express either dysfunctional hERα or do not express hERα at all.
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This similarity in gene expression can be attributed to tumor-intrinsic factors rather than to patient-specific factors.
Alterations in the concentration ratios within one nucleoside group can be attributed to tumor-associated changes in expression and activities of the involved modifying enzyme systems.
This is attributed to tumor cell proliferation during fractionated radiotherapy.
The death was attributed to tumor progression based on liver biopsy.
This state of "concomitant" tumor immunity has been attributed to tumor tolerance via active immune suppression mechanisms exerted by tumor-specific suppressor T cells [ 3, 4].
On the other hand, we observed a significant association with tumor size parameter (P = 0.026) and that this significance was attributed to tumor size range from 1.5 to 3 cm.
This therapeutic resistance has recently been attributed to tumor stem-like cells due to their unrestrained self-renewal capacity and the ability to maintain tumorigenic potential at the single cell level, thereby evading both resection and radiotherapy [ 4- 7].
However, the beneficial potential of adoptively transferred T cells turned out to be more pronounced if autologous tumor infiltrating lymphocytes (TIL) instead of isolated CTL clones were administered to patients, an effect that was attributed to tumor-specific CD4+ T cells present among the TIL infused [8] [10].
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