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A significant proportion of the phenotypic variation in any organism can be attributed to polymorphisms at the DNA level.
Thus, such disparities in sensitivity to vitamin D may be attributed to polymorphisms in the VDR gene.
Since most of the Nicotiana spp nucleotide entries in GenBank correspond to N. tabacum, a percentage of the mismatches may be attributed to polymorphisms in the 3' UTR of mRNAs from N. attenuata and this tobacco species.
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Currently, it is thought that hotspot diversity in natural human populations can be attributed to polymorphism of the Prdm9 ZFA.
These person-to-person differences, which are attributed to polymorphisms in the genes encoding for the respective enzymes, might define subpopulations of women with higher lifetime exposure to hormone-dependent growth promotion, or to cellular damage from particular oestrogens and/or oestrogen metabolites.
Individual variation in perception of this odorant has been attributed to polymorphisms in OR7D4 (Keller et al. 2007) and segregates with a near Mendelian inheritance pattern in the population.
Inter-individual variations in TNF-A levels have been attributed to polymorphisms, notably the A allele at -308 (G/A) position in the promotor region of the TNF gene, which has been associated with higher TNF-A transcription levels [ 21] and an increased risk of several types of cancer [ 22].
Much of this variability can be attributed to genetic polymorphisms.
Inter-individual variability in drug response can often be attributed to genetic polymorphisms in genes encoding drug metabolizing enzymes, transporters, ion channels and drug target receptors (1- 4).
For site-specific methylation, thus, it is advisable to evaluate whether the observed associations may be attributed to nearby polymorphisms, which may be unbalanced by exposure levels by chance.
We further examined if the variable sensitivity to cisplatinum observed in CAFs from lung cancer could be attributed to functional polymorphisms in genes critical for cellular response to cisplatinum such as TP53, ERCC1, and Mdm2.
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