All cells show some degree of Erk activation (indicated by the presence of nuclear Erk), which can be attributed to pathway activation by soluble EGF present in the culture medium.
Widely separated glioma lesions that can not be attributed to the pathways just mentioned are called multicentric gliomas [ 11, 149].
This could be attributed to different pathways of p53 dysfunction in HPV-positive and HPV-negative tumours (Crook et al, 1991), but also to other cell cycle-related changes that could affect radiosensitivity (Pyeon et al, 2007).
However, this discrepancy indicates that the phenotypic changes induced by chronic inhibition of extracellular VEGF did not necessarily depend on compensatory pathways activated by VEGF family ligands, and can most likely be attributed to other pathway(s).
Plasminogen activator inhibitor-1 protein levels were also moderately reduced in scrambled control compared with non-transfected cells, which could be attributed to RNAi pathway saturation and/or secondary off-target effects affecting PAI-1 pregulatoryulatory factors, as previously described for other cases (Grimson et al, 2007; Khan et al, 2009).
Mammalian target of rapamycin (mTOR) regulates a range of pathways (such as translation of certain proteins, cell division, etc)., and its major side-effects can be attributed to autophagy independent pathways.
This slightly higher mass loss in geopolymer composites containing 1 wt% carbon and basalt fibre than the pure geopolymer paste can be attributed to the additional pathways for water to escape that were created by the fibre matrix interface.
The different patterns of lytic proteins induced by 5-AzaC vs TPA plus NaB might be attributed to different signaling pathways involved in viral reactivation.
Since HDAC inhibition affects several pathways that could potentially have an impact on DNA repair, compromised DNA repair upon HDAC inhibition could also be attributed to several other pathways besides the ones investigated in this study.
This could be attributed to different exposure pathways, exposure doses and threshold effects.
