While some of this can be attributed to off year elections and the inherent lack of publicity compared to presidential elections, I feel safe in saying that a lot of it also has to do with poor GOTV efforts.
Likely, discrepancies between our findings and prior studies can be attributed to off target inhibitor effects since frequently used inhibitors ALLN, ALLM and calpastatin have all been reported to inhibit several other proteases and/or the proteosome [25], [26], [27], [28].
Similar results were observed in SIRT6 KD cells generated with the other SIRT6 shRNA; thus, the changes in DNA-PKcs mobilization cannot be attributed to off-target shRNA effects.
Compared with those estimates, our estimated incidence of 2.89 per million worker-years suggests that 14 24% of occupational pesticide poisoning may be attributed to off-target drift from agricultural applications.
For example, genetic studies have suggested that depletion of mammalian cyclin dependent kinase 2 (CDK2) shows almost no effect whereas inhibition with chemical inhibition, such as this, shows dramatic effects that cannot be attributed to off-target effects.
The first SphK2 selective inhibitor described, ABC294640, has been tested in a variety of animal models of disease with some success, but some of the effects observed in in vivo studies may be attributed to off-target effects of this low-potency compound.
The reduced cooling capacity was attributed to off design operation.
The effect was attributed to off-target effects of the drug on a sub-population of resistant cells giving rise to increased secretion of factors promoting osteolysis.
Indeed hypertension, a common and potentially dangerous side effect of FosD, has been attributed to off-target inhibition of VEGFR (D'Cruz and Uckun, 2012).
As described in a previous study (Woodward et al., 2007), the antagonist effects were never totally surmounted by 10 μ M prostamide F2α; this has been attributed to off-target activity for prostamide F2α at prostanoid FP receptor in the feline iris (Matias et al., 2004; Spada et al., 2005).
