It is unknown whether this isolate's failure to form biofilms can be attributed to mutation, perhaps post-isolation, or phenotypes segregating in natural populations.
In these cancers, CIN can often be attributed to mutation in DNA repair genes, suggesting that the drive behind tumor development is the increase in spontaneous genetic mutation resulting from a lack of appropriate management of DNA damage [ 48].
Thus, a change in genotype in a patient with Whipple disease must be interpreted as an infection with a different strain and cannot be attributed to mutation of the original strain.
The relatively high rate of recombination in V. cholerae means that the level of sequence similarity does not indicate relatedness of the isolates unless the sequences are very similar and differences can be attributed to mutation, as in the toxigenic strains.
Dividing the yeast Rfa2 NT into three subregions revealed that all of the growth defects, DNA-damage defects, and genetic interactions we observed could be attributed to mutation of subregion 1 (aa 3 14) and/or subregion 3 (aa 30 40) of the N-terminus (Table 3).
Downregulation or absence of WWOX mRNA expression in various types of cancer can be attributed to mutation, homozygous deletion, chromosomal translocations within or near the WWOX locus, hypermethylation of the promoter region or alterations in transcriptional control (Paige et al, 2001; Ludes-Meyers et al, 2003; Ishii et al, 2003).
Most of autosomal dominant familial AD can be attributed to mutations in one of three genes: those encoding amyloid precursor protein (APP) and presenilins 1 and 2. Most mutations in the APP and presenilin genes increase the production of a small protein called Aβ42, which is the main component of senile plaques.
In the past two decades, several diseases have been found to be able to be attributed to mutations in genes that encode proteins involved in human Fe−S cluster biogenesis.
In conclusion, the CpdA resistance of the R0.8 line cannot be attributed to mutations in the identified CARP genes or to reduced CARP transcript levels.
Less than 40% of familial breast cancer can be attributed to mutations in the high-risk genes BRCA1 and BRCA2 despite their high penetrance [ 1, 2].
