Sentence examples for be attributed to epigenetic from inspiring English sources
In the latter case, IGF2 induction could be attributed to epigenetic mechanisms: hypermethylation was observed at the H19/IGF2 intergenic region and enrichment of histone marks associated with active chromatin was observed at the IGF2 promoter.
62, 63 This predisposition may, in part, be attributed to epigenetic changes in gene expression, resulting from undernutrition related stressors during intrauterine development.
Sporadic MSS-CRCs behave differently compared to their MSI counterparts, and the latter differ from CRCs arising in LS; the differential behavior can at least in part be attributed to epigenetic alterations and their associations with other molecular markers [ 50].
These low correlations can be attributed to epigenetic factors, translation rates, and protein degradation rates, but they can also be due to the levels being assessed for different samples, across different time points.
The differential expression of lnc-AL355149.1-1, lnc-C22orf32-1, and lnc-ZNF674-1 observed in NPC might be attributed to epigenetic regulation including microRNA, DNA methylation, and histone modification.
Death in this system was attributed to epigenetic repression through recruitment of histone deacetylases to transcription hot-spots in the nucleus.
In human cholangiocarcinoma, sustained IL-6/Stat3 signalling, enhanced Mcl-1 expression and resistance to apoptosis, is attributed to epigenetic silencing of SOCS3 by promoter hypermethylation [ 70].
Susceptibility to diet-induced obesity has been attributed to epigenetic changes in adipose tissue gene expression, including genes involved in the Wnt signaling pathway [ 28].
In humans, reports of reduced hMLH1 and hMSH2 expression in NSCLC have varied from ∽18%to61%1% and these decreases have typically been attributed to epigenetic silencing.
GISTs from CT patients do not manifest SDHX mutations; however, these tumors are also SDH-deficient, and the molecular underpinning of CT GIST has been attributed to epigenetic silencing of the SDHC gene [ 14].
In this study, we established that miR-375 is among the most significantly downregulated miRNAs in trastuzumab-resistant breast cancer cells, which is attributed to epigenetic mechanisms involving DNA methylation and histone deacetylation.
