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In the current study, we demonstrated for the first time that the functional status of pancreatic islet microvascular vasomotion was impaired in SHRs and that hemodynamic disturbance of pancreatic islet microvascular vasomotion might be attributed to elevated blood glucose level.
Our data suggested that the MMF-induced GI disorders were likely related to local inflammatory reactions, which may be attributed to elevated NO and myeloperoxidase activities that result in pathological injuries.
Decrease in photosynthetic rate may be attributed to elevated levels of heavy metal accumulation that can adversely affect electron transport as well as photosynthetic metabolism (Burzyhski and Zurek 2007).
The reduction of full-length APP in CHO/hAPP cells (Fig. 5G H) can be attributed to elevated intracellular and extracellular cleavage of APP.
The low plasma pyridoxal 5'-phosphate level in patients with rheumatoid arthritis may also be attributed to elevated pyridoxal phosphatase activity during inflammation.
The enhanced level of proteolysis could be attributed to elevated activity of the ubiquitin proteasome pathway, as immunoblot analysis detected increased amounts of ubiquitinated proteins in C2C12 myotubes exposed to C26 CM.
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Moreover, increased performance of soil biota has been attributed to elevated primary productivity [11], [24].
The hyperlipidemia was attributed to elevated FFA and cholesterol synthesis by the liver and adipose tissue caused by activation of SREBP1c and 2, whereas studies in cultured liver cells support the notion that ritonavir might cause a decreased degradation of nascent apoB attributable to inhibition of the 20S proteasome.
Clinical manifestations of HBV reactivation were attributed to elevated HBV-DNA replication and liver injury.
All other acute GI toxicities of grade ≥3 (10%) were attributed to elevated aspartate/alanine aminotransferase.
However, null homozygotes suffered embryonic lethality at E10.5-11.5 due to compromised cardiovascular development that was attributed to elevated Notch1 expression.
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