Many pharmacological effects of silymarin can be attributed to effects downstream or upstream of its antioxidative and membrane-stabilizing properties.
Genetic variation can be attributed to the downstream effects of inherited mutations, environmental factors, or inaccurately resolved errors in transcription and replication.
Taken together, these data suggest that the enhanced stress tolerance of the BnaABF2-expressing transgenic plants can be attributed to expression of downstream genes such as these LEA class genes and ABA-induced stomatal closure (Figs. 6, 9).
Another possible reason can be attributed to the genes downstream of the CBF regulon, which lack functional CRT/DRE elements in the promoters of genes that are required in order to affect chilling acclimation response or freezing tolerance.
Accordingly, the observed PTEN impact on survival is not likely to be attributed to functions of downstream effectors but rather PTEN genetic aberration itself, which may represent the biological and clinical characteristics of tumour.
Again, more stringent analysis of genes modulated in multiple conditions and cell types was characterised by an increase in the proportion of observed changes that can be attributed to primary and downstream miR-181b activity.
Lower variability of full-length initiation may be attributed to its location downstream of the uORF and to the fact that it is efficiently used already under steady-state conditions, but the molecular mechanisms driving the preferential use of the uORF initiation codon under favorable translational conditions remain to be identified.
The lower concentrations of pharmaceuticals in samples downstream of NY3 compared to samples downstream of NY2 can be attributed to the high amount of dilution (0.17% of flow derived from effluent downstream of NY3, compared to 15%−24% for the other two sites; see Table S-3) at this site.
The formation of the Liaohe River hotspot can be attributed to the post-reform development of downstream Liaohe River Plain and large cities including Shenyang, which, with a large demand for labor, attracted a floating population of many ethnic minorities from the surrounding areas.
Although these results are promising and suggest that targeted inhibition of eIF4E phosphorylation may be a valid therapeutic approach, it remains unclear to what extent the efficacy of MNK kinase inhibitors can be attributed to their ability to block other downstream phosphorylation targets critical for tumour growth and maintenance.
