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Epidemiological studies involving mutation testing of cases unselected for their family history are showing that perhaps less than 20% of familial aggregation on a population basis can be attributed to deleterious mutations in these two genes [ 23].
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Many of these can be attributed to the deleterious effects of chronic graft-versus-host disease.
Many of these can be attributed to the deleterious effects of cGVHD.
Segregation distortions reported here may also be attributed to the presence of deleterious recessive genes as has been observed in C. gigas, O. edulis and P. martensii, however, further research is warranted to confirm this.
The higher mortality rate for animals with the susceptible genotypes could be attributed to preclinical scrapie or to possible deleterious effects of some PrP alleles in the presence of scrapie in the flock.
Because patients are never restricted to dark-only conditions, the above observation may be attributed to the activation of an unknown yet deleterious rhodopsin signaling pathway(s) specific to the mislocalized Class I rhodopsin mutants.
Recent experiments suggest that these deleterious effects can be attributed to an acute loss of vascular patency due to clot formation induced by damage to ovarian arterial endothelial cells.
This deleterious effect might be attributed to the fact that RBC units transfused in this study were not leukocyte-reduced, in contrast to the RBC units used in the study by Lacroix and colleagues.
It is tempting to speculate that age- and diet-induced stresses that promote deleterious mitochondrial function could be attributed to the convergence, at least in part, to the overexpression of MKP-1 in skeletal muscle.
This observation can be attributed to the fact that the analysis does not distinguish deleterious mutations from those that confer an activating effect.
Much of the deleterious effects of asbestos can be attributed to the sustained synthesis of reactive oxygen species (ROS) which in turn results in DNA damage [ 5- 7] and oxidative stress within the cell.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com