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The nature of PTEN localization in the nuclei can be attributed to binding by one ubiquitin modification, which also produces a delay in electrophoretic mobility.
The primary mechanism by which PRO 2000 inhibits HIV infection is binding to viral gp120, although some activity may be attributed to binding to CD4 receptors on target immune cells [19].
Clearly, the differential effects of these closely related arsenicals demonstrate that the observed changes in selenoprotein synthesis likely would not be attributed to binding to a vicinal dithiol.
Thus, virtually all of the oncogenic effects of TRIM33 can be attributed to binding to a single site in the genome, a remarkable discovery.
In contrast, the estimated clearance of ALX-0061 after single intravenous doses of 0.4 to 10 mg/kg was much lower, and can be attributed to binding of the HSA binding domain to serum albumin.
Secretion of RANKL by galectin-8-treated osteoblasts can be attributed to binding of galectin-8 to receptor complexes that positively (uPAR and MRC2) and negatively (LRP1) regulate galectin-8 function.
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The sensitivity improvement was attributed to binding of OH− ions to edge defect sites, but the binding characteristic was not thoroughly determined.
Therefore, the uptake of chAb 14C5 seen in αvβ5 − Colo16-bearing animals is attributed to binding on CAFs in the tumor stroma and/or on neo-vasculature of the tumor.
Electromobility shift assay showed that the rs45454293 polymorphism, but not rs3850641, affects the binding of nuclear factors, thus suggesting that the lower transcriptional activity is attributed to binding of one or more transcriptional repressor(s) to the T-allele.
Its anthelmintic action has been attributed to binding to the helminth β-tubulin, leading to depolymerization, cell cycle arrest and death [ 17, 18].
Inhibition of hIK1 and Kv1.1 potassium channels by polyunsaturated fatty acids has also been attributed to binding to the central cavity.
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