Participants who presented with serious adverse events suspected to be attributable to study drugs were withdrawn from receiving further study drugs, but follow-up visits and healthcare continued.
These differences may also be attributable to study design.
While early indications of a potential benefit may have been attributable to publication bias [ 86, 87] the positive effects of later large studies may be attributable to study design and cultural effects.
9 11 13 Differences may be attributable to study design features including location, the selection of a control group unexposed to helmet legislation, whether baseline trends in injury rates were modelled, and whether surrogates were used for cycling rates and if so, which ones.
Many key discoveries that have contributed to our understanding of the basis and mechanisms of life and also to significant advances in health care are attributable to studies that employed HeLa cells.
Nine serious adverse events occurred in group I vs 12 in group P; none was attributable to study medication.
Most of the variability in prevalence estimates was attributable to study heterogeneity (I = 98%, p < 0.001) (Fig. 2), both from developed (I >99%; p < 0.001) and developing countries (I = 98%; p < 0.001) (Figs. S1 and S2, respectively).
Twelve per cent of patients in the PPX arm and 16% of patients in the docetaxel arm died within 30 days of treatment, but only 2% of these deaths were attributable to study drugs, 9% appeared to be disease related, and 3% were due to comorbidities.
The findings reported by Bugg et al. agree with our finding of an increased risk of AIP with HP; this agreement may be attributable to both studies' adoption of a highly specific definition of AIP.
A possible reason for the absent main effects of personal characteristics could also be attributable to the study design.
