Since p53 decreases global histone H3 S10P [ 4, 34] the observed decrease in histone H3 S10P following HPV E6 RNAi is likely to be attributable to p53 induction.
These liver and kidney effects might be attributable to liver enzyme induction and accumulation of α2u-globulin, respectively, and are presumably induced by the parent compounds, although this has not been thoroughly investigated (Doi et al. 2007).
This high number of detected proteins could be attributable to the possibly higher induction of a large subset of enzymes during SCB SSF, and/or the high sensitivity of the LTQ Orbitrap Velos system.
In contrast, Ono et al (2001) demonstrated that the absence of CDDP-induced apoptosis in p53-defective TCC cells, established CDDP-resistant sublines from the TCC cell line T24, may be attributable to a loss of p73 induction that would be followed by insufficient caspase activation.
In order to examine whether the protective effects of HO-1 induction / over-expression could be attributable to its ability to generate CO (as suggested by the data presented in Figure 2), we examined the ability of the CO-donor, CORM-2, to protect cells against A β toxicity.
This might be attributable to release of factors into the blood or CSF, or neurotransmitter-mediated induction of these genes in multiple brain regions.
Thus, the hypoxic induction of Nur77 by β-catenin does not seem to be attributable to changes in β-catenin/TCF-dependent nuclear signalling.
This may be attributable to IL-8 production mediated by stimulated peritoneal or pleural macrophages and the subsequent induction of lymphocyte chemotaxis into the body cavities.
The induction and enhancement of chondrocyte apoptosis by HIF-2 α appears to be attributable to its capacity to increase Fas expression.
