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Collectively, we hypothesized that the adverse impact of upregulated AFAP1L1 expression on the treatment outcomes of CRCs might be attributable to enhanced cell motility and increased anoikis resistance, rather than to enhanced invasion capability through the degradation of the surrounding matrix.
Based on the present results it could be hypothesized that this effect may in part be attributable to enhanced remyelination.
The phenotypes of Camelina AtPAP2 OE lines may be attributable to enhanced enzyme activity during sucrose synthesis.
This may be attributable to enhanced cell cycle checkpoint arrest, preventing proliferation and activating apoptosis in cells damaged by radiotherapy [9], [25].
The increased incidence of outbreaks due to Norovirus may be attributable to enhanced detection or reporting; however, similar increases were noted in North Carolina, New York and Wisconsin [ 34].
Liposomal DXR showed a modest, but better antitumour effect compared with free DXR in all gastric cancer xenograft models tested, which could be attributable to enhanced liposomal accumulation in tumour tissue (Papahadjopoulos et al, 1991), known as passive targeting.
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The increased memory cells in Cdc42−/− mice are attributable to enhanced proliferative renewal.
Resistance to platinum is attributable to enhanced DNA repair.
11 As the survival curves diverged with time, the authors questioned whether improved mortality was attributable to enhanced removal of cytokine-rich peritoneal fluid.
In previous studies, CMA of human pluripotent stem cell lines have identified a CN gain of chromosome 20q11.21 shared in >20% of hESC lines and 18% of human induced pluripotent stem cells, and the cells containing this amplicon have a higher population doubling rate, which is attributable to enhanced resistance to apoptosis [ 15– 15].
Holloway et al. have shown recently that an elevation in NF-κB activity is attributable to enhanced growth factor signaling through ERK1/2; inhibiting this NF-κB activity, either pharmacologically or through the expression of a constitutively active IκB, partly restores ER activity and expression in these cells.
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