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In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [37].
In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [ 37].
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Furthermore, we observed that AGEs-induced cell migration was attenuated by using LY294002, a PI3K/AKT inhibitor, in macrophages.
These outer cladding back reflections are attenuated by using a higher index gel drop in the constant section of the DCTF (see Fig. 2(a)).
27 Our group has previously shown that preterm-at-term AT deposition can be attenuated by use of fortified human milk.
It did not require novel protein synthesis nor did it show extensive nuclear fragmentation, but it was attenuated by use of caspase inhibitors.
In observational studies, skeletal muscle mass loss is attenuated by use of insulin sensitizers in older men with diabetes (36).
HIF-1 activity might also be attenuated by previously used chemotherapeutics such as anthracycline and doxorubicin, which act by inhibiting HIF-1 α DNA-binding activity, and acriflavine, which prevents HIF subunit dimerisation [ 130, 131].
This effect appeared to be attenuated by the use of inhaled corticosteroids, but was not affected by smoking.
Potential immunogenicity can be attenuated by the use of modified or "humanized" antibodies [90] and single-chain antibodies [43,82].
Shorter questionnaire versions can hardly include specific questions about the different pharmacological groups being assessed, which may compromise recall, and the potential for a lower burden may be attenuated by the use of more complex questions or a less attractive appearance, with many questions concentrated in a small area [ 10, 11].
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