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The negative effects of increased IAP on the thoracic cavity can be attenuated by increasing the pleural pressure, effectually placing an opposing force on the IAP [36, 37].
Although the decrease may partially be attenuated by increasing levels of sex hormone binding globulin (SHBG) [ 2], obesity has a major independent impact on the decrease in these levels [ 3].
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In parallel, the beneficial effect of a high omega-3 PUFA diet on infarct size can be attenuated by increased omega-6 PUFA consumption.
Fasted critically ill rabbits lost weight, which was attenuated by increasing intravenous glucose load.
The vulnerability of individuals with the metabolic syndrome (MetS) to cardiovascular events (CVEs) is attenuated by increased cardiorespiratory fitness (CRF), despite the presence of obesity as a usual component of MetS.
The decrease in serum VLDL-TG levels was attenuated by increase in non-VLDL-TG levels in patients with non-cirrhotic CH-C, resulting in comparable total TG levels.
Although it has not been investigated whether circulating ADMA influences eNOS expression, the inhibitory effect of ADMA in the pulmonary vascular tone may be attenuated by the increased NOS protein expression as we found in our yak study.
In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [37].
In mechanically ventilated patients with acute lung injury, the degree of hyperoxia-induced adsorption atelectasis could at least be attenuated by using higher PEEP levels: increasing PEEP from 5 to 14 cm H2O completely blunted the fall of the PaO2/FiO2 ratio from 200 to 150 mm Hg induced by increasing the FiO2 from 0.6 to 1.0 [ 37].
The presence of increased oxidative stress in different tissues of IR and diabetic animals has also been reported, such as a NO synthase dysfunction in Goto-Kakizaki rats, which could be attenuated by exercise [ 46], and increased ROS production in aortas of streptozotcin-diabetic mice, that was reverted by aminoguanidine administration [ 47].
This increase can be attenuated by lung-protective ventilation with low tidal volumes and application of positive end-expiratory pressure [ 34].
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