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These features implicated the pro-BII subpopulation of B cells with activated mTOR signaling, and the pre-BI subpopulation of B cells with activated and unresponsive pre-B cell receptor signaling, to be associated with relapse.
While there is a lack of well-designed studies investigating the post-relapse treatment outcome, available evidence gives sufficient cause for concern that, in addition to the considerable psychosocial risks, an additional risk of biological harm may be associated with relapse.
Similarly, the total number of tablets overused was not measured at baseline, which previously has been reported to be associated with relapse at follow-up [13, 16].
An initial seven questions were designed to encourage self-examination and allow the reporting of symptoms that may be associated with relapse, either locoregional or metastatic.
The excluded patients differed significantly from the included patients on variables shown to be associated with relapse (e.g., younger age, prior hospitalizations, poorer adherence, and more severe symptoms), suggesting that the overall rate of relapse has likely been underestimated.
However, because the prognosis of BCP-ALL with TCF3-PBX1 fusion has improved dramatically in the last decades, TP53 mutations might not be associated with relapse in this subgroup.
Similar(51)
Concentric collapse of the tracheal lumen is less common, and it may be associated with relapsing polychondritis [74].
Meanwhile, the less frequent and disperse haplotypes might be associated with relapses.
Early discontinuation of antidepressant therapy is associated with relapse and increased costs.
On univariate analysis several factors were associated with relapse including current medications and markers of asthma severity.
The dopamine D1 receptor, which is typically overexpressed in the normal adolescent prefrontal cortex, is involved in drug cue responses and is associated with relapse in animal models.
More suggestions(12)
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