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In addition, increased susceptibility to develop PD appears to be associated with polymorphisms in lysosomal genes such as those associated with Gaucher disease and Niemann-Pick disease.
The course of the disease itself does not seem to be associated with polymorphisms of the GR.
On the other hand, Japanese patients with sarcoidosis were reported to be associated with polymorphisms specific for haplotype S02 [ 36].
Clinical factors Risk for late onset Alzheimer's disease is known to be associated with polymorphisms of the apolipoprotein E (ApoE) gene; people with an ε4 allele have an increased risk of both familial and sporadic forms, accounting for 20-50% of the attributable risk.
Markers in low copy number genic regions, such as expressed sequence tag (EST -derived sourcEST -derivedlikely to be asourcesed with polymorphisms conferring trare effects and are preferred in agricultural plants, however these moreers generalikelyhibitoreduced rates of polymorphism [ 13, 14].
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And high TS expression is now well known to be associated with polymorphism of the 28-base pair tandem repeat sequence (VNTR) in the TS promoter enhancer region (TSER) [ 35].
Lately it has become clear that the risk of developing CD is associated with polymorphisms in several genes that are involved in interaction with bacteria.
One school of thought favors the idea that common genetic diseases are associated with polymorphisms that are present in relatively high frequency in a population (common disease/common variant model).
HLA-B*81 was associated with polymorphisms at positions 177 (E found in 97% of sequences), 182 (Q in 88%) and 186 (T in 91%); both residues 182 and 186 are embedded in the epitope TPQDLNTML (B*8101) (Figure 5).
NS or HA also have been associated with polymorphisms thought to impact dopamine and serotonin synthesis or metabolism, e.g., catechol-O-methyl transferase (COMT, [25]) and tryptophan hydroxylase-2 gene (TPH2 [26]).
Susceptibility to rUTI and/or pyelonephritis in humans is associated with polymorphisms in the genes for non-secretor blood group antigens, P1 phenotype, CXCR1, TLR1, TLR2, TLR4, and TLR5 [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [49].
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