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Almost all of the terms were found to be associated with "Pathways in Cancer" which was also supported by the recent literature works [ 16, 37, 59- 66].
In the pairwise comparison, 21 differentially expressed genes were found to be associated with pathways that are involved with changing metabolites.
In addition slow progression could be associated with pathways including specific cellular proteins, such as restriction factors, APOBEC3, TRIM5, and Tetherin.
Differences in gene expression were found to be associated with pathways intimately related with cell adhesion, cell proliferation, growth regulation and cell death (P<0.05).
Many of the transcription factors are known to be associated with pathways that may be related to phases or transitions in the yeast metabolic cycle, such as the diauxic shift, response to oxidative stress, or cell cycle initiation.
To narrow the large universe of genes that could possibly be examined, we focused our attention on GO terms that may be associated with pathways related to recently proposed hypotheses [ 13].
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The chemokine receptors CCR2, CCR5, and CXCR3 are associated with pathways implicated previously in aneurysm pathogenesis.
The largest number of modules were associated with pathways involved in regulation of gene expression (nine modules), immune function (seven modules) and metabolism (seven modules).
About 20% of differentially regulated genes were associated with pathways involved in cell growth and differentiation.
With respect to the signaling pathways active in recurrent AO, the identified proteins were associated with pathways responsible for cell growth (Figure 1B).
The majority of the upregulated genes were simultaneously downregulated in female PD alone (Figure 2A, Table 2), including several genes that are associated with pathways related to PD pathogenesis such as ST13, MAPT, XPO1, SLC11A2, DNAJC7, KCNN3, APBA2 and TNS1.
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