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These results strongly suggest that an antibody response to brain antigens induced by P. falciparum infection may be associated with pathogenic mechanisms in patients developing CM.
Not surprisingly, many of the protein families we identified are likely to be associated with pathogenic processes such as plant cell wall degradation, toxin biosynthesis, formation of reactive oxygen species and detoxification [5].
In fact, MERRF has been previously reported to be associated with pathogenic mutations of the mitochondrial tRNAPhe gene [ 22].
Large-diameter stimuli that are more likely to be associated with pathogenic particles nucleate large-scale receptor clusters, forming a signaling complex called a phagocytic synapse.
Conserved proteins among the filamentous fungi may be implicated in their morphogenesis, while non-conserved, species-specific genes might be associated with pathogenic capabilities [ 16, 17, 80- 85].
Furthermore, the most significant methylation changes that may be associated with pathogenic processes appear to be very stable over time in FLS lines.
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For instance, members of the family of the serine protease autotransporters of the Enterobacteriaceae (SPATE) have been associated with pathogenic strains and are among the virulence proteins predominantly secreted by the pathogens of this family [ 4].
Toxin-antitoxin genes are often transferred through horizontal gene transfer and are associated with pathogenic bacteria, having been found on plasmids conferring antibiotic resistance and virulence.
TNFα has been associated with pathogenic processes leading to CM [17].
Elevated plasma levels of cytokines in SIVmac251 infected animals provide additional evidence that immune activation is associated with pathogenic infection.
Type III secretion system (TTSS), which has been associated with pathogenic mechanisms in a wide variety of bacteria, is now recognized as potential virulence factors of non-O1, non-O139 strains as well as V. parahaemolyticus [31] [33].
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