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STAT3 has been reported in several previous genome-wide association studies (GWAS) to be associated with immune relevant diseases such as Crohn's disease (Barrett et al. 2008; Franke et al. 2008; Yamazaki et al. 2013), inflammatory bowel disease (Jostins et al. 2012), and multiple sclerosis (Jakkula et al. 2010; Patsopoulos et al. 2011; Sawcer et al. 2011).
The purposes of this study were to determine (1) the extent and distribution of inflammatory cells, and (2) to test the potential association of cells believed to be associated with immune reactions to debris particles in joint capsular and interface tissues of failed, nonMOM hip implants.
Expert review of the cases suggested that the disease likely was acquired through sexual contact and that it appeared to be associated with immune dysfunction caused by exposure to some factor that predisposed the affected individuals to opportunistic infection.
Around 300 points were found to be associated with immune control of HIV, all in regions of chromosome six that code for HLA proteins.
TiO2 NP exposure resulted in cardiac inflammation coupling with pulmonary inflammation, which may be associated with immune dysfunction and imbalance of Th1-related cytokine expression and Th2-related cytokine expression in mouse heart.
Although numerous basic science studies in orthopedics have suggested that orthopedic trauma injuries may be associated with immune responses that facilitate sepsis [15, 16, 17, 18], it is currently unclear whether orthopedic trauma patients are at increased risk for developing sepsis or septic shock.
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Heparin (unfractionated or low molecular weight) and glycoprotein IIb/IIIa-inhibition can be associated with immune-mediated thrombocytopenia of clinical importance.
We analyse 118,989 single-nucleotide polymorphisms (SNPs) across 186 loci known to be associated with immune-mediated diseases in the largest candidaemia cohort to date of 217 patients of European ancestry and a group of 11,920 controls.
Interestingly, some of these differentially expressed miRNAs, including miR-146, have been previously reported to be associated with immune-related signal pathways in mammals.
One melanoma treatment, ipilimumab, may be associated with immune-related adverse events that may lead to therapeutic benefit (Downey et al, 2007; O'Day et al, 2007).
Anti- M.tb directed immune responses may be associated with immune-protection, yet also with immune-pathology, as shown for IL-17-driven cellular immune responses.
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