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Exact(13)
We constructed genetic risk scores [ 21] for height and BMI using 179 and 32 variants, respectively, previously reported in genome-wide association studies (GWAS) to be associated with height [ 23] and BMI [ 24].
Another hypothesis is that cryptorchidism may be associated with height, although Taskinen and Wikstrom (2004) found no evidence of this association.
There was significant overlap between the 14 genes involved in OGID and 611 genes in regions identified in GWASs to be associated with height (p = 6.84 × 10−8), suggesting that a common variation impacting function of genes involved in OGID influences height at a population level.
The estimated effect size of the GHRHR haplotypes is considerably higher than that of other SNPs found to be associated with height [2] [4], [22], [23].
The last SNP is located downstream of the gene, but their data does not include an analysis of haplotypes spanning the part of the GHRHR gene we found to be associated with height.
Early length growth seems to be associated with height in adulthood (1).
Similar(47)
In exploratory analyses, each of the TBMD and LBMD Z-scores was associated with height Z-score, with the association following a straight line with a change in the line's slope at height Z-score = −0.5.
Further, a variant in RAD51L1 reported in Lango Allen et al. (12) as being associated with height also showed suggestive evidence of association with primary tooth eruption in this study.
One of the genes they found had already been associated with height changes in other populations, but the rest hadn't.
The GHRHR gene is located in this region and typing of tagSNPs identified a haplotype that is associated with height (p = 0.00077) in the original study population.
In previous studies a haplotype of ESR1 defined by the SNP rs2234693 was associated with height in females and young boys [23], [24].
More suggestions(20)
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