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We hypothesize that higher initial levels of depressive symptoms, and more pronounced growth in these symptoms, will be associated with harmful alcohol use [ 11, 12].
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(A level of 10 µg/dL is associated with harmful effects on children's learning and behavior).
Others have shown negative impacts: for example, in a prospective cohort study, hyperoncotic albumin infusion was associated with harmful effects on renal function and outcome [3].
In addition, we excluded trials with agents that are associated with harmful effects such as torcetrapib or hormones.
The use of kerosene fuel is associated with harmful effects that have been documented in a few studies.
High levels of alcohol consumption in pregnancy are associated with harmful effects such as fetal alcohol syndrome [ 1].
Although up-regulation of sympathetic activity is necessary for regulation of blood pressure, hyperreactivity is associated with harmful effects, including the development of hypertension.
Although angiotensin II sensitization is necessary for regulation of blood pressure, hyper-reactivity is associated with harmful effects, including the development of hypertension.
In contrast, increased risk of S pneumoniae BSI was associated with harmful alcohol consumption, while risk was reduced among patients with diabetes or those receiving haemodialysis (table 2).
Yet, there is also the larger population of MSM whose substance use is infrequent, but for whom it is associated with harmful use and HIV risk.
Identification of difficult patients is valuable not only regarding resource use but in particular as high utilisation is associated with harmful side effects [ 16, 17].
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