Some of them are already known to be associated with genetic diseases, while associations of most other genes are still not known.
Polymorphisms of iNOS and endothelial nitric oxide synthase are also reported to be associated with genetic risk of developing lupus, although associations with renal disease are less clear [ 106, 107].
Even common inflammatory skin dermatoses were revealed to be associated with genetic mutations, such as atopic dermatitis and its association with mutations in filaggrin gene (FLG), coding for filaggrin.
"Narcolepsy is a complex disease and its causes are not yet fully understood but it is generally considered to be associated with genetic and environmental factors, including infections.
CNVs are local gains or losses of regions in the genome owing to duplication or deletion that can be associated with genetic disease6 and which should be detectable by variation in the average DNA sequence coverage of the region.
Congenital cataracts can also be inherited, can be associated with genetic, metabolic, or other infectious diseases and disorders, or may have no known cause or association.
Although the causes of sleepwalking are not fully understood, the disorder in many instances appears to run in families and hence may be associated with genetic factors.
There are a host of diseases that seem to be associated with genetic mutations; however, many of the mutations that have been discovered are not within actual genes, which makes it difficult to understand what functional changes the mutations cause.
