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Getting older might be associated with frailty and other negative stereotypes, but at Huff/Post 50, we think people only get better with age.
Through follow up genotyping of selected candidates in the entire CHS cohort, we identified mt204 to be associated with frailty.
Psychosocial variables found to be associated with frailty included anxiety, poor wellbeing, depression and low sense of control (mastery).
Besides the OPQOL total score, a number of characteristics of the older subjects were found to be associated with frailty (Table 1 and Additional file 1).
One possibility is chronic/persistent Cytomegalovirus (CMV) infection, as positive anti-CMV immunoglobulin G titers have been shown to be associated with frailty.
Consistent with this theory, cardiovascular disease, increased white matter lesion burden, and stroke have been found to be associated with frailty in older adults.
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St. John et al. (2013) investigated whether depressive symptoms were associated with frailty, whether there is a gradient effect on the continuum of depressive symptoms, and whether the association between the syndromes is specific for certain depressive symptoms, such as positive and negative affects, somatic complaints and interpersonal relationships.
Another possible explanation besides the possible causal chain mentioned above, is the fact that cardiac abnormalities might act as predictors for frailty, since in the Cardiovascular Health Study, frailty has been shown to predict falls in older persons and in this same cohort it has also been shown that subclinical cardiovascular disease was associated with frailty [32], [33].
It is associated with frailty, falls, and poor functional outcomes.
Clinical OA is associated with frailty and pre-frailty in older adults in European countries.
Vitamin D has been associated with frailty in many studies on elderly populations [ 24– 26].
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