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Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting.
Therefore, it would be plausible to speculate that some identified genetic variants associated with exercise phenotypes could also be associated with exceptional survival.
We speculated that some genetic variants that influence exercise phenotypes could be associated with exceptional survival (i.e. reaching ≥100years of age).
Finally, the RasGrf1 gene has recently been found to be associated with exceptional longevity in humans [ 10].
Compression of disability and/or morbidity towards the end of very long lives has been noted to be associated with exceptional longevity which in turn has been found to be strongly familial [ 2- 4].
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Thus, identifying those genetic variants that are associated with exceptional longevity and rate of decline of physical function at the end of the human lifespan is of potential medical relevance.
Genotype data of additional SNPs in Table 7 provide further evidence for the existence of variants in the region between physical positions 1340K and 1500K of chromosome 10 that are associated with exceptional longevity.
In humans, delayed puberty (slow development) is associated with exceptional longevity [ 97].
Moreover, long telomeres have been associated with exceptional longevity and increased lifespan [ 21].
Our results document in dogs a female sex advantage for achieving exceptional longevity and show that lifetime ovary exposure, a factor not previously evaluated in women, is associated with exceptional longevity.
To move closer to understanding the mechanistic underpinnings of sex differences in human longevity, we studied pet dogs to determine whether lifetime duration of ovary exposure was associated with exceptional longevity.
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