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Capecitabine is activated to 5-FU by CES, CDA and TYMP, of which SNPs in CDA and CES2 were found to be associated with efficacy and toxicity.
However, there is likely variation in how the model is implemented in clinical practice, which may be associated with efficacy, and therefore variation, in outcomes.
These subtypes have preferential sites for distant relapse [ 7, 8], and the subtype may also be associated with efficacy of systemic cancer therapies [ 9, 10].
86, 87 Polymorphisms in the IgG fragment C receptor affecting ADCC have been shown to be associated with efficacy of those antibodies.
There is evidence that a combination of both, ChEI and Gb, may be superior to a monotherapy with only ChEI or Gb and will be associated with efficacy and less side effects, as shown in an exploratory trial with donepezil and EGb 761®[ 35].
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This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in methotrexate transmembrane transporters and adenosine receptors are associated with efficacy and/or toxicity of the drug.
It has recently been proposed to check two levels of vancomycin and calculate the AUC because a single time-point trough does not represent the concentration time curve that is associated with efficacy [15].
Although several clinical variables have been associated with efficacy and safety, they are often unrealistic in clinical practice.
Then we evaluated whether the methylation status by each method was associated with efficacy of anti‐EGFR treatment.
Both maximum concentration/minimum inhibitory concentration (Cmax/MIC) and AUC0-24/MIC (area under the curve over 24-hour dosing interval/MIC) have been associated with efficacy [ 13- 15].
Historically, this type of exercise has been associated with efficacy in reducing body fat mass and improving aerobic fitness and whole-body insulin sensitivity.
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