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In our analyses, tumors located at the head of the pancreas were less likely to be associated with distant metastasis.
Our data suggests that, in esophageal squamous cell carcinoma, nm23-H1 gene product expression may not be associated with distant metastasis.
Of special interest, four genes (GGH, FAAH, PIR and TAF5L) among the identified 51-gene signature were significantly found to be associated with distant metastases [ 3, 4].
A synonymous single nucleotide polymorphism (SNP) rs172378 (A>G, Gly−>Gly) in the complement component C1QA has been proposed to be associated with distant breast cancer metastasis.
Reduced expression of this gene has been shown to be associated with distant metastasis and poor prognosis in breast cancer (Toyama et al, 2003), indicating that it may be a potential tumour suppressor and antimetastasis gene.
the breast preservation rate should not have been reported as an endpoint as it was not predetermined by the protocol and, therefore, it is subject to bias no aesthetic outcomes were reported loco-regional recurrences are likely to be associated with distant metastases and an increased risk of death.
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Microvessel density in NSCLC is associated with distant metastatic spread and poor survival [37].
A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor.
Our study demonstrates that increased cyclin E expression is associated with distant metastases for whichever histological component of nephroblastoma it is assessed in.
Thirteen emm types are associated with distant STs: five emm types are associated with >two distant STs and eight emm types are found among a single pair of distant STs, whereas five emm types are associated with three or more distant STs (Table 4).
A hypoxic profile that included 13 genes such as VEGF and ANGPTL4, has been associated with distant metastases and might represent an independent predictor of outcomes in primary breast cancers [27].
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