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In contrast, sites under negative selection were more likely to be associated with destabilizing disease-causing mutations.
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Mmu-miR-451 is known to destabilize cytokine mRNAs [ 21] and mmu-miR-363 is known to be associated with regulation of MAPK signaling [ 22].
People love to be associated with success".
It may be associated with Banksia oblongifolia.
While stabilizing the CBM-KD interaction and inducing formation of the C-interacting helix is associated with AMPK activation, destabilizing the interaction by mutating S108 in β1-containing AMPK complexes reduces AMPK activity.
While several of these maladies are associated with mutations that destabilize the native TTR quaternary and/or tertiary structure, wild-type TTR amyloidogenesis also leads to the degeneration of postmitotic tissue.
The lack of snc1/ snc1 genotypes among the wild-type F2 progeny suggested that the destabilized cpr1 allele is associated with wild-type morphology in the F2 generation.
The restabilization of destabilized colloidal particles, which was associated with higher residual turbidities, occurred at dosages above the optimum.
SpvB ADP-ribosylates actin, destabilizes the cytoskeleton and is associated with host cell cytotoxicity (Lesnick et al., 2001; Tezcan-Merdol et al., 2001; Kurita et al., 2003; Browne et al., 2008).
Several highly expressed miRNAs have been associated with the development and progression of breast cancer, in which their aberrant expression is presumed to destabilize mRNAs encoding crucial tumor suppressors and differentiation-promoting factors [ 72, 73].
We also found that the TG/ del (P1527), destabilizing dinucleotide deletion, combined with the A1626G polymorphism in the 3′ UTR of the CD24 gene are associated with significantly lower level of CD24 protein (p = 0.026).
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