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14 Alternatively, it has been proposed that enzalutamide resistance may be associated with cellular Fas-associated death domain-like interleukin 1β-converting enzyme inhibitory protein (c-FLIP) expression, which is a key regulator of caspase-8 (FLICE -promoted apoptosis.
The observed patterns can be associated with cellular functions and processes, and they also show association with expression level, location relative to nearby genes, and CpG content.
Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation.
Whether the observed microvascular dysfunction could also be associated with cellular or mitochondrial alterations cannot be ruled out from this study [44].
The most surprising results were the wide biological response involving a large set of genes differentially expressed between different absorbed doses and that few of the genes currently known to be associated with cellular radiation damage were differentially expressed, which implies an organ-specific response to ionizing radiation.
Oxidative exposure of cells occurs naturally and may be associated with cellular damage and dysfunction.
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Telomere attrition is associated with cellular ageing, whilst telomere maintenance is a prerequisite for malignant transformation.
In addition, most of the molecular functions deregulated during the first 48 h were associated with cellular rearrangement.
Genome architecture is associated with cellular identity, but how this organization changes during reprogramming is not well understood.
High levels of O6-methylguanine-DNA methyltransferase (MGMT) or a defective mismatch repair (MMR) system, are associated with cellular resistance to triazenes.
However, AAV vectors have a limited cloning capacity of <5 kb and have been associated with cellular immune responses against the delivered gene products.
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