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Neonatal lactic acidosis can be associated to severe inborn errors of metabolism.
The presence and the extent of anti-microbial serological response was found to be associated to severe bacterial infections overall and the time to first infection was also shorter in patients with multiple seropositivity.
Previous studies identified Attention Deficit rather than ADHD symptoms to be associated to severe prematurity [ 21, 22].
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Especially Gram-negative bacteria, including multidrug resistant Acinetobacter baumannii and Enterobacteriaceae producing Extended-spectrum beta-lactamases (ESBL) and carbapenemases, have been associated to severe healthcare-associated infections and their occurrence has increased in the last decades [ 1, 3].
During pandemic and postpandemic period, several pathogens cocirculated and were associated to severe respiratory infections, with influenza A(H1N1 pdm09 virus having the greatest impact.
During pandemic and postpandemic period, several pathogens cocirculated and were associated to severe respiratory infections; however, influenza A(H1N1 pdm09 virus had the greatest impact (58.3%) in our SARI/ARDS series.
Scores of 4 or more were associated to severe bloating.
Strains typed as vacA s2/ cagA+/ iceA+/ oipA+ were more prevalent than those typed as vacA s1/ cagA+/ iceA+/ oipA+ and which are associated to severe pathologies.
Tumor infiltration by T-cells expressing this marker has been associated to severe prognosis in different tumors, including ovarian and lung cancers [ 8].
While patients with WRN mutation have to cope with an accumulation of DNA damage, LMNA mutant cells are associated to severe structural alterations in the nucleus, leading to chromatin reorganization and subsequent epigenetic alterations.
Though a genotype-phenotype correlation has not been well established for PDH deficiency, these findings suggest that this particular mutation could be associated to a severe outcome, underlining the need to counteract long-term developmental impairment as much as possible.
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