The existence of an edge between HDL and AD in our network provides clear proof of principle that PHPN can detect relationships between two PTs known to be associated through a validated biological mechanism.
For example, a disease d and a process p which are not linked through any common gene might be associated through a miRNA which regulates a gene g d, involved in d, and a gene g p, involved in p. This introduces a new layer of associations between genes and processes inferred based on miRNAs annotations.
Hashimoto's is associated, through a group of underlying genes, with more serious autoimmune disorders, including juvenile diabetes, rheumatoid arthritis, lupus, multiple sclerosis and Graves' disease, which causes hyperthyroid, or overproduction of thyroid hormone.
The tissue specimen and clinical data for each subject were associated through a unique study identifier.
It is possible that cynical hostility scores and TL or TA were associated through a relationship with a third separate factor.
The term deformation is often used to denote the fact that the observed images are associated through a nonlinear dense transformation or spatially varying deformation model [ 6].
PTEN consists of two domains, the phosphatase domain and catalytic domain (C2), which are associated through an extensive interface.
The flagellum, which protrudes from a flagellar pocket, is associated through the basal body, with a single mitochondrion containing a network of circular DNA, called the kinetoplast [1] [4].
An unadjusted model in which RA features and metabolic syndrome factors were associated through univariate analysis, and an adjusted model in which RA features were correlated with insulin-sensitivity parameters after adjustment for these classic risk factors through multiple regression also were carried out.
Combined effects of rs553668 and rs10885122 in haplotype analysis Although, in combined SNP analysis, the haplotype-bearing minor alleles of rs553668 and rs10885122 (haplotype AT) were very infrequent (0.7%), this haplotype was associated through meta-analysis with an approximately 0.45 mmol/l higher fasting glucose level (p < 6 × 10−18 for two copies) than the common haplotype (Fig. 3a).
