Thus, both the quantity of cholesterol and its distribution among lipoprotein fractions are shifted in the knockout mice to a pattern known to be associated in humans with risk of atherosclerosis.
Next, we investigated whether the human orthologs of rat genes either shared between or uniquely mutated in rat disease models had been associated in human genome-wide association studies (GWAS) for hypertension, metabolic phenotypes, or their complications.
Finally, to determine if mTOR signaling and GDF15 are associated in human tumor samples, we used the same tumor tissue array as in Table 2, and performed IHC staining for phospho-S2448 mTOR (Fig. 5E).
Moreover, prenatal stress and alterations in offspring HPA axis function has also been associated in humans.
In addition, the reduction of transcallosal projections is associated in humans with deficiencies in abstract reasoning and problem solving (25, 26).
SNPs in this gene were associated, in humans, with "fasting serum aspartate aminotransferase" and "urinary free epinephrine excretion per day" [ 62].
This chemical, formed in foods during high-temperature cooking, is classified as reasonably anticipated to be a human carcinogen by the National Toxicology Program and has been associated in humans with reduced birth weight and head circumference.
The CombitTA-BCR-ABL-p190 mice expressing the BCR-ABL p190chimeric gene product have previously been described to consistently show the B-ALL pathologic phenotype with which this oncogene is associated in humans [ 20].
They have been associated in the human with premature birth [ 7, 8] and increased chance of allergies and asthma [ 9– 11].
Also, exposure to heavy metals has been shown to be associated sirenomelia in humans.
