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MDR can be performed by an open source software mdr2.0 and model goodness-of-fit and significance can be assessed using software mdrpt1.0 [ 8] or in the MDR.R R software package [ 9].
For example, FDG-PET can be assessed using software that analyses the pattern of tracer uptake voxel-wise by comparing the subject's scan with a reference data set of normal ageing, allowing a better recognition of the patterns of hypometabolism compared with visual interpretation [ 15, 17, 27].
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Genotypic associations were assessed using software Plink v1.07 and SHEsis [ 14, 15].
Statistical significance of Fst estimates was assessed using software Arlequin with 10,000 permutations.
Data will be assessed using SPSS software (V.21; SPSS Inc, Chicago, Illinois, USA).
These images may be assessed using computer software and various algorithms to attempt to separate particulate populations from one another.
In the NELSON study, approximately 98% of the nodules were solid, and thus could be assessed using semi-automated software.
Human radiation dose was assessed using OLINDA software.
Brain MRI lesion volume in FLAIR and T1-weighted images was assessed using MIPAV software.
Locus by locus cytonuclear disequilibrium was assessed using the software CNDWin [59], with 10,000 Markov Chain Monte Carlo repetitions.
Amino acid conservation at the missense mutations was assessed using SIFT software (http://sift.jcvi.org/) and Polyphen was used to predict the effect of the variation on the protein (http://coot.embl.de/PolyPhen/).
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