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Newer agents, notably bisphosphonates and metformin, have shown promise in observational studies and need to be assessed in randomised prevention trials.
The efficacy of conformal radiotherapy in the treatment of locally advanced non-small-cell lung cancer should be assessed in randomised clinical trials (recommendation).
However, the true merits of chemotherapy can only be assessed in randomised trials incorporating the stratification for risk factors and the measurement of quality of life.
The answer is no - observational data should be interpreted with caution and should mainly be used to identify risks, while safety must be assessed in randomised clinical trials.
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Only a few of these methods (marked*) have been assessed in randomised trials [ 20- 22].
34 The effect of low-carbohydrate diets on CHD events has not been assessed in randomised controlled trials.
Corticosteroid-free remission (CDAI <150 without concomitant corticosteroids) was assessed in randomised responders regardless of baseline corticosteroid use (n = 329) and also for randomised patients taking corticosteroids at the baseline of CHARM, regardless of response to induction therapy (n = 206).
18 19 CYP2C9 and VKORC1 gene effects on warfarin dosing are perhaps the best established pharmacogenomic associations in the cardiovascular literature and are the only markers for which a test and treat strategy has been assessed in randomised trials.
Global functioning had not been assessed in randomised trials of Art Therapy for people with schizophrenia that had been completed when the study was being planned, so data on mean GAF scores and standard deviations were taken from previous trials of Compliance Therapy and Cognitive Therapy for people with schizophrenia.
The efficacy of conformal radiotherapy in the treatment of locally advanced non-small-cell lung cancer should be assessed in a randomised clinical trial (option).
One recent correlation study found dual therapy NRT to be associated with smoking cessation in women attending English SSSP [ 37], although this has yet to be assessed in a randomised control trial.
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CEO of Professional Science Editing for Scientists @ prosciediting.com