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Pathway alternatives can be assessed at http://www.alternativesignalingpathways.com, developed with this review article.
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Availability: A GPL licensed software implementation in Perl for analysis and spectrum annotation is available in the supplementary material and a web server can be assessed online at http://www.compbio.dundee.ac.uk/prophossi Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online.
All the allelic variants described can be assessed consulting the database at http://www.ucl.ac.uk/ldlr/Current/index.php?select_db=LDLR.
Patient-reported QoL will be assessed using the EQ-5D questionnaire (available at http://www.euroqol.org) at baseline, each monthly visit, Day 180 and at the post-treatment follow-up visit.
The enrichment in Gene Ontology (GO) terms was assessed by using EASE, at http://david.abcc.ncifcrf.gov.abcc.ncifcrf.gov
Transmembrane domains were detected using the TMHMM software available at http://www.cbs.dtu.dk/services/TMHMM/ and signal sequences were assessed using the SignalP software available online at http://www.cbs.dtu.dk/services/SignalP/.dtu.dk/services/SignalP/
Fluorescence intensity was assessed using Image J program available at http://rsbweb.nih.gov/.
Nucleotidic similarity with the NCBI genetic database was assessed using the BLAST tool (available at http://www.ncbi.nlm.nih.gov/blast/Blast.cgi).nih.gov/blast/Blast.cgi
The quality of the microarray experiments was assessed with affyPLM and Affy, found at Bioconductor http://www.bioconductor.org.
Sequence similarity was assessed using ClustalW2, available at [http://www.ebi.ac.uk/Tools/clustalw2/].
The database can be accessed at http://203.199.182.73/gnsmmg/databases/dstho.html.
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