Sentence examples for be ascribed to mutations from inspiring English sources

Our analysis demonstrated that the vast majority of differences in the frequency of substitution between LTRs and flanking NRRs could be ascribed to mutations possibly affecting cytosines (G C ->A T) which are targets of DNA methylation.

Since there were no PKU patients in our sample, the obtained result cannot be ascribed to mutations responsible for PKU.

More recently it was also recognized that about 30% of idiopathic dilated cardiomyopathies can be ascribed to mutations of sarcomeric proteins (reviewed in [ 1]).

More than 5,000 distinct diseases have been ascribed to mutations that result in deficiencies of critical enzymes.

A number of disorders have been ascribed to mutations in genes encoding sodium channels and further genetic insights have been provided by analysis of targeted sodium channel mutations and gene deletion in mice (Table 1).

In the meantime, other forms of EBS have been ascribed to mutations in the plectin gene, such as EBS with pyloric atresia (EBS-PA; OMIM #612138) and EBS-MD with myasthenic syndrome (EBS-MD-MyS).

Cobalamin C (CblC) disease is the most common inherited disorder of vitamin B12 metabolism, and has been ascribed to mutations in the methylmalonic aciduria and homocystinuria type C protein (MMACHC) gene that result in downstream deficiencies in methylcobalamin and adenosylcobalamin, which serve as enzymatic cofactors for MTR and methylmalonyl-CoA mutase (MCM) respectively.

Activation of the Ras pathway in cancer is marked by the loss of the intrinsic GTPase activity of the Ras protein, which can be ascribed to missense mutations in codons 12 and 13 of exon 1, which are responsible for 90% activating mutations in the of the K-ras gene [ 8].

Thus, the differences in α and β for w(d) and wneut(d) must be ascribed to compensatory mutations.

Moreover, any genetic change that occurred in the breast prior to puberty would probably be manifest as a detectable (clonal) mutation in normal adult breast tissue, and an unwarranted significance might be ascribed to that mutation.

Consequently, the shortness of highly expressed genes could not be ascribed to local mutation bias.