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Two of the seven trials included in the meta-analysis of OS could not be included in our analysis of surrogacy because the definition of PFS could not be ascertained reliably in spite of in-depth review of the case report forms.
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The most meaningful associations are those in which all the relevant factors can be ascertained reliably.
CONCLUSION: Retinal microvascular characteristics, especially computer-assisted quantification of generalized retinal arteriolar narrowing, can be ascertained reliably by standardized photographic grading methods, supporting the validity of their associations with cardiovascular disease.
We recognise that an RVharm/target(i) may not be ascertained reliably.
We initially investigated whether cluster residency status could be ascertained reliably from a written description of household location.
A response frequency could be ascertained unambiguously in most cases.
Exposure to environmental factors during pregnancy is not reliably registered and can thus only occasionally be ascertained in retrospective studies.
Some irritating vacation behaviors cannot be ascertained in advance, no matter how hard one tries.
Their calorie content can easily and reliably be ascertained.
Cases of most neurodegenerative conditions are difficult to define and ascertain reliably in population-based sample, and there are problems in relating events and the effects of different exposures to defined 'at-risk' populations.
Jitterbug is substantially more precise than RetroSeq in all regions (insertion sites) that can be ascertained by PacBio long read technology, i.e. that PacBio reads can be reliably aligned to.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com