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Although the exact mechanism for strand discrimination is yet to be ascertained, it has been shown in case of humans and yeast that the endonucleolytic activity is resident in the MutL homolog [9], [10], [11].
If ancestral and genetic subgroups can be ascertained, it is also important for genetic association studies taking place in that region because typical self-reported race data may not adequately control for substructure confounding.
Particularly, because the denominator data (numbers of travellers) cannot be ascertained, it is not possible to calculate incidence rates.
When the identity of the p75NTR-ir profile could not be ascertained, it was categorized as unknown.
Because a complete cohort of the grower's employees could not be ascertained, it was not possible to fully characterize their birth defect risk.
Non-responders were more likely to be known to be working in a Pacific Island state, and for the 16 where location could not be ascertained, it is plausible that a disproportionate number might have resided outside New Zealand.
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Genetic mapping also can be carried out directly in rodent models, and when similar phenotypes are ascertained, it is highly likely that the biological processes that lead to a disease will be shared between humans and mice.
We also observed that the proportion misclassified as smokers increases with age, suggesting that once patients' smoking status has been ascertained, it is not routinely updated, so that the accuracy of this information reduces as time passes.
Whether or not this model will "work" cannot be ascertained unless it's adopted.
The assumption is that it was recovered in the 19th century, although where and when cannot be ascertained, nor is it clear why it was only published as late as 1972.
He said the method should be useful in any kind of genetic engineering where genes must be inserted at a specific site, and in any genome project where the function of an unknown gene could be ascertained by disrupting it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com