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For example, PGE1 elicits cAMP accumulation at discrete sites within cells [ 34], suggesting that locally confined, modest changes in cAMP levels, which may be arduous to detect via RIA, may suffice to mediate changes in the activity of downstream effectors such as PKA.
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Photograph by Clifford Ross It is fitting that these images were arduous to capture.
Asking people for eliciting thought is arduous to cause this gap.
Third, most of the patterns are of very small size and it is arduous to extract interesting relationship among items.
This film was arduous to make.
Environmental persistence of multidrug-resistant (MDR) organisms in hospital environment is arduous to reduce or eliminate.
Liberty's ascent would be arduous — Sisyphean, to mix in a little Greek mythology.
It ought to be arduous, but it is instead compelling.
The registration process can be arduous and take three to four months.
And the fight was going to be arduous.
But that shopping can be arduous in a market not set up to respond to consumers.
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