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Furthermore, a recent study in a preclinical model identified α2β1 as a suppressor of breast cancer metastasis [ 42], in contrast with the pro-tumorigenic functions that have been described for other β1 integrins such as α3β1 and α6β1 [ 11, 43, 44], emphasizing the need to identify individual integrins with cancer-promoting roles that would be appropriate to exploit as therapeutic targets.
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The protein micro array approach which we exploited turned up to be appropriate to test a total of almost 350 human sera against over 100 bacterial antigens, demonstrating that this technology should be taken into account whenever large sets of data on in vivo expression of pathogen antigens and on the subsequent host immune response are required.
While Mr. Bush's advisers said it was appropriate to highlight his stewardship of the nation after the attacks, the commercials also drew outcries from many people who said the campaign was exploiting a national tragedy for political gain.
It is thus considered the most appropriate to exploit further qPCR-based screening approaches (see also Querci et al. [ 7] for a more elaborate discussion).
Chronic and frequent treatment schedules have been reported as the most appropriate to exploit the antiangiogenic effect of cytotoxic drugs, compared to the high-dose/intermittent-schedule mainly targeting tumour cells (Hanahan et al, 2000; Miller et al, 2001).
Possibly the most striking one is the reduction of beak length appropriate to exploit the flatter fruits of the invasive tree (Carroll et al. 1998, 2001, 2003; Dingle et al. 2009).
It seems appropriate to exploit this wealth of technology available for humans also for other species.
At its poignant climax, we learn that even this story - a labor of love conceived and performed by Deal - would be appropriated and exploited for personal gain by the non-Native man he had trusted as a friend and colleague on the project.
As one recent statistical review of these alternative approaches concluded, 'when circumstances are appropriate, the failure to exploit modern statistical methodology and information technology is indefensible in present day clinical trials' [ 6]. Bartlett chose one of the more straightforward (and intuitively compelling) alternative statistical techniques known as 'adaptive randomization'.
This approach is appropriate for exploiting frequency correlation between subcarriers in OFDM systems [29, 30], but it is not so useful for temporal correlation, because the interpolated CSI is already outdated at the time it is available.
Appropriate nicknames were coined to exploit his new currency, among them Bambino, the Big Bam, the Sultan of Swat and, courtesy of The Times, the Caliph of Crash.
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