This could represent selection bias; for example, unstable fractures in the lower limbs may pose such a significant problem for patients and caregivers that surgical stabilization may be appropriate even when patients have a limited expectation of survival.
Especially for futility analyses, it is important to consider whether the trial can usefully contribute to an overview that could provide a definitive answer, but when the patient population is limited or there are no similar ongoing trials a decision to stop a trial in favour of standard treatment (or no treatment) can, in our view, be appropriate even when there is overall clinical uncertainty.
Nevertheless, findings provide important clinical insight, including that parent-led treatments are appropriate even when the parent is highly anxious and that it may not be necessary to adjust interventions for many families.
In one sense the visual metaphor was appropriate; even when voices and instruments formed dense, teeming ensembles, every contribution still registered distinctly — less a matter of isolation than one of style.
I imagine that was the original idea, but I'm not sure it was appropriate even when I graduated in 1967.
(There are times when a one- or two-page resume is appropriate even for scientists, such as when they're seeking nonscientific positions in sales, marketing, business development, or even technical support or medical communications).
The characterization of protein complexes, including their composition and subunit interactions, is crucial to understanding how these protein complexes function, and MS based tools are often appropriate even when the sample is too complex for other tools, when the complex will not crystallize, or when the complex is too large for NMR or too small for cryo-EM.
So we get into a pattern of urgent action, even when it's not appropriate, even when we realize that the way were are doing things is actually making the problem worse".
And what it evokes most powerfully is an unalloyed, ungovernable joy in the creative act itself, a fierce performer's delight that's always welcome and always appropriate, even when the character he's playing is an unhappy one.
It's about forming a way of thinking that has become so entrenched that it seems appropriate, even when it's not, and is a fall-back that soon grows to fit many situations beyond the one in which the critical personality initially arose.
Opponents of dilemmas can say that one of the requirements overrides the other, or that the agent faces a disjunctive requirement, and that regret is appropriate because even when he does what he ought to do, some bad will ensue.
