From the clinical perspective, this begs the question as to whether miRNAs are appropriate agents for ovarian cancer therapy.
The former will be appropriate for many agents (especially where there is a solid body of data for the drug as a single agent or in combination with cytotoxic chemotherapy).
In terms of the involvement of 5-HT in bronchial carcinoids, SFN can be an appropriate agent for carcinoid therapy as it has been reported to reduce the expression of 5-HT receptors including 5-HT2, 5-HT3 and serotonin transporter (SERT) as well as to affect the release of 5-HT in Caco-2 cells [ 31].
Phase 1 clinical trials experts have suggested that an MTD-seeking approach may not be appropriate for antineoplastic agents with mechanisms of action that are distinct from conventional cytotoxic drugs (Parulekar and Eisenhauer, 2004).
Based on its well-established use as a lipid-lowering agent and efficacy when combined with many antidiabetes and/or lipid-lowering therapies, colesevelam may be an appropriate agent for use throughout the type 2 diabetes continuum, including in high-risk patients (with prediabetes) as well as late in the disease.
Traditional dose-limiting toxicity (DLT) definition, which uses grade (G) 3 4 toxicity data from cycle 1 (C1) only, may not be appropriate for molecularly targeted agents (MTAs) of prolonged administration, for which late or lower grade toxicities also deserve attention.
Sigma receptors are highly expressed in human tumors and should be appropriate targets for developing tumor imaging agents.
Subcutaneous agents may be appropriate for and preferred by some patients.
Today, chemopreventive agents may be appropriate for high-risk patients such as patients with isolated HGPIN, elevated PSA, and negative biopsy, but are not appropriate for routine recommendation.
Conversely, those predicted to be less responsive, or to have a worse prognosis, may be appropriate for studies of novel agents or approaches.
