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As a result, this strategy should be approached with due caution.
It is, however, important to realize that the outlier QC results should be approached with due caution.
In particular, our study was limited to the use of only two murine tumour cell lines and only one angiogenesis inhibitor, so extrapolation to human subjects and other drugs that target the VEGF pathway should be approached with due caution.
On the other hand, the apparent plasticity of proglucagon-expressing enteroendocrine cells (or precursors), which is reminiscent of that of pancreatic α-cells (Thorel et al., 2010), suggests that attempts to increase the number of these cells (for example in obesity or T2D), through the regulation of tumour suppressors or growth factors, should be approached with due caution.
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However, strategies that involve inhibition of VEGF pathways must also be approached with caution due to the central role played by VEGF in many normal cellular processes.
However, the result should be approached with caution due to the small number of individuals meeting the criteria for inclusion in the selected homogeneous group (boys with ADHD n = 24, reference group n = 139).
Although serosurveys have proven to be a fundamental tool for disease surveillance, interpretation of antibody results in this study has to be approached with caution due to the lack of specific controls for roe deer [ 45].
These prospects provide exciting new directions for preventative health care but would require careful monitoring and should be approached with caution due to the extensively documented carcinogenic properties of H. pylori.
The use of antimicrobials needs to be approached with caution due to potential problems of drug resistance and possible reactions of some micro-organisms: entero-haemorrhagic E coli (EHEC) may release toxins more readily when a person is treated with certain drugs, potentially causing severe illness[ 13].
Concerning the tumour site analysis, we had noted in the article that the results should be approached with caution due to the small sample sizes available, and we highlighted the need for more studies investigating individual cancer sites and involving less common ethnic groups in the conclusion.
Due to the retrospective nature of the study the results are not definitive and should be approached with caution.
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